Excision of viral reprogramming cassettes by Cre protein transduction enables rapid, robust and efficient derivation of transgene-free human induced pluripotent stem cells

Integrating viruses represent robust tools for cellular reprogramming; however, the presence of viral transgenes in induced pluripotent stem cells (iPSCs) is deleterious because it holds the risk of insertional mutagenesis leading to malignant transformation. Here, we combine the robustness of lenti...

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Detalles Bibliográficos
Autores principales: Kadari, Asifiqbal, Lu, Min, Li, Ming, Sekaran, Thileepan, Thummer, Rajkumar P, Guyette, Naomi, Chu, Vi, Edenhofer, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055111/
https://www.ncbi.nlm.nih.gov/pubmed/24713299
http://dx.doi.org/10.1186/scrt435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055111/
https://www.ncbi.nlm.nih.gov/pubmed/24713299
http://dx.doi.org/10.1186/scrt435

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