Shear stress-induced mechanotransduction protein deregulation and vasculopathy in a mouse model of progeria

INTRODUCTION: A mouse model of progeria derived by insertion of the human mutant LMNA gene (mLMNA), producing mutant lamin A, shows loss of smooth muscle cells in the media of the ascending aorta. We hypothesized that high shear stress, in the presence of mutant lamin A, induces this vasculopathy an...

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Detalles Bibliográficos
Autores principales: Song, Minjung, San, Hong, Anderson, Stasia A, Cannon III, Richard O, Orlic, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055145/
https://www.ncbi.nlm.nih.gov/pubmed/24661531
http://dx.doi.org/10.1186/scrt429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055145/
https://www.ncbi.nlm.nih.gov/pubmed/24661531
http://dx.doi.org/10.1186/scrt429

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