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Muscle Structure Influences Utrophin Expression in mdx Mice
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disorder caused by mutations in the dystrophin gene. To examine the influence of muscle structure on the pathogenesis of DMD we generated mdx(4cv):desmin double knockout (dko) mice. The dko male mice died of apparent cardiorespiratory fail...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055409/ https://www.ncbi.nlm.nih.gov/pubmed/24922526 http://dx.doi.org/10.1371/journal.pgen.1004431 |