Cargando…

Protective Immunity Based on the Conserved Hemagglutinin Stalk Domain and Its Prospects for Universal Influenza Vaccine Development

Influenza virus surface glycoprotein hemagglutinin (HA) is an excellent and chief target that elicits neutralizing antibodies during vaccination or natural infection. Its HA2 subunit (stem domain) is most conserved as compared to HA1 subunit (globular head domain). Current influenza vaccine relies o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khanna, Madhu, Sharma, Sachin, Kumar, Binod, Rajput, Roopali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055638/ https://www.ncbi.nlm.nih.gov/pubmed/24982895 http://dx.doi.org/10.1155/2014/546274

Ejemplares similares

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain
por: Steel, John, et al.
Publicado: (2010)

Diagnostic Potential of Recombinant scFv Antibodies Generated Against Hemagglutinin Protein of Influenza A Virus
por: Rajput, Roopali, et al.
Publicado: (2015)

An Inactivated Influenza Virus Vaccine Approach to Targeting the Conserved Hemagglutinin Stalk and M2e Domains
por: Sun, Weina, et al.
Publicado: (2019)

The influenza virus hemagglutinin head evolves faster than the stalk domain
por: Kirkpatrick, Ericka, et al.
Publicado: (2018)

An immuno-assay to quantify influenza virus hemagglutinin with correctly folded stalk domains in vaccine preparations
por: Rajendran, Madhusudan, et al.
Publicado: (2018)

Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain
por: Anderson, Christopher S., et al.
Publicado: (2017)

An Adenovirus-Vectored Influenza Vaccine Induces Durable Cross-Protective Hemagglutinin Stalk Antibody Responses in Mice
por: Kim, Eun Hye, et al.
Publicado: (2017)

Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model
por: Roubidoux, Ericka Kirkpatrick, et al.
Publicado: (2021)

A single-shot adenoviral vaccine provides hemagglutinin stalk-mediated protection against heterosubtypic influenza challenge in mice
por: Bliss, Carly M., et al.
Publicado: (2022)

Publisher Correction: Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain
por: Anderson, Christopher S., et al.
Publicado: (2018)

Publisher Correction: Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain
por: Anderson, Christopher S., et al.
Publicado: (2018)

Adjuvants and Immunization Strategies to Induce Influenza Virus Hemagglutinin Stalk Antibodies
por: Goff, Peter H., et al.
Publicado: (2013)

Hemagglutinin Stalk Antibody Responses Following Trivalent Inactivated Influenza Vaccine Immunization of Pregnant Women and Association With Protection From Influenza Virus Illness
por: Dhar, Nisha, et al.
Publicado: (2020)

Development and characterization of influenza M2 ectodomain and/or hemagglutinin stalk-based dendritic cell-targeting vaccines
por: Olukitibi, Titus Abiola, et al.
Publicado: (2022)

Globular Head-Displayed Conserved Influenza H1 Hemagglutinin Stalk Epitopes Confer Protection against Heterologous H1N1 Virus
por: Klausberger, Miriam, et al.
Publicado: (2016)

Assessing the Protective Potential of H1N1 Influenza Virus Hemagglutinin Head and Stalk Antibodies in Humans
por: Christensen, Shannon R., et al.
Publicado: (2019)

Analysis of the conserved protective epitopes of hemagglutinin on influenza A viruses
por: Jiao, Chenchen, et al.
Publicado: (2023)

Pandemic influenza virus vaccines boost hemagglutinin stalk-specific antibody responses in primed adult and pediatric cohorts
por: Nachbagauer, Raffael, et al.
Publicado: (2019)

Influenza Vaccination Results in Differential Hemagglutinin Stalk-Specific Fc-Mediated Functions in Individuals Living With or Without HIV
por: Motsoeneng, Boitumelo M., et al.
Publicado: (2022)

Strategies Targeting Hemagglutinin as a Universal Influenza Vaccine
por: Bullard, Brianna L., et al.
Publicado: (2021)

Age Dependence and Isotype Specificity of Influenza Virus Hemagglutinin Stalk-Reactive Antibodies in Humans
por: Nachbagauer, Raffael, et al.
Publicado: (2016)

A Carboxy-Terminal Trimerization Domain Stabilizes Conformational Epitopes on the Stalk Domain of Soluble Recombinant Hemagglutinin Substrates
por: Krammer, Florian, et al.
Publicado: (2012)

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
por: Pardi, Norbert, et al.
Publicado: (2018)

Immunogenicity of modified vaccinia virus Ankara expressing the hemagglutinin stalk domain of pandemic (H1N1) 2009 influenza virus
por: Di Mario, Giuseppina, et al.
Publicado: (2017)

Two Conserved Residues Are Important for Inducing Highly Ordered Membrane Domains by the Transmembrane Domain of Influenza Hemagglutinin
por: Ge, Mingtao, et al.
Publicado: (2011)

Identification and In Silico Characterization of a Conserved Peptide on Influenza Hemagglutinin Protein: A New Potential Antigen for Universal Influenza Vaccine Development
por: Khalaj-Hedayati, Atin, et al.
Publicado: (2023)

“Breathing” Hemagglutinin Reveals Cryptic Epitopes for Universal Influenza Vaccine Design
por: Wu, Yan, et al.
Publicado: (2019)

Strategies targeting hemagglutinin cocktail as a potential universal influenza vaccine
por: Liu, Xuejie, et al.
Publicado: (2022)

Conserved epitopes of influenza A virus inducing protective immunity and their prospects for universal vaccine development
por: Staneková, Zuzana, et al.
Publicado: (2010)

Hemagglutinin stalk-based monoclonal antibody elicits broadly reactivity against group 1 influenza A virus
por: Huang, Jingjin, et al.
Publicado: (2020)

Protection against Multiple Subtypes of Influenza Viruses by Virus-Like Particle Vaccines Based on a Hemagglutinin Conserved Epitope
por: Chen, Shaoheng, et al.
Publicado: (2015)

Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody
por: Raymond, Donald D., et al.
Publicado: (2018)

VLPs containing stalk domain and ectodomain of matrix protein 2 of influenza induce protection in mice
por: Shi, Lili, et al.
Publicado: (2023)

The Hemagglutinin-Neuraminidase (HN) Head Domain and the Fusion (F) Protein Stalk Domain of the Parainfluenza Viruses Affect the Specificity of the HN-F Interaction
por: Tsurudome, Masato, et al.
Publicado: (2018)

Conserved structural RNA domains in regions coding for cleavage site motifs in hemagglutinin genes of influenza viruses
por: Gultyaev, Alexander P, et al.
Publicado: (2019)

Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer Mouse Challenge Model
por: Jacobsen, Henning, et al.
Publicado: (2017)

Hemagglutinin stalk-binding antibodies enhance effectiveness of neuraminidase inhibitors against influenza via Fc-dependent effector functions
por: Zhang, Ali, et al.
Publicado: (2022)

Neutralizing Antibodies Targeting the Conserved Stem Region of Influenza Hemagglutinin
por: Nath Neerukonda, Sabari, et al.
Publicado: (2020)

Pre-existing Hemagglutinin Stalk Antibodies Correlate with Protection of Lower Respiratory Symptoms in Flu-Infected Transplant Patients
por: Aydillo, Teresa, et al.
Publicado: (2020)

Rational design of an influenza-COVID-19 chimeric protective vaccine with HA-stalk and S-RBD
por: Li, Yulei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0sf126imb6d2stud9gm3s3a48d