A Novel Functional Role for MMSET in RNA Processing Based on the Link Between the REIIBP Isoform and Its Interaction with the SMN Complex

The chromosomal translocation t(4;14) deregulates MMSET (WHSC1/NSD2) expression and is a poor prognostic factor in multiple myeloma (MM). MMSET encodes two major protein isoforms. We have characterized the role of the shorter isoform (REIIBP) in myeloma cells and identified a clear and novel interac...

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Detalles Bibliográficos
Autores principales: Mirabella, Fabio, Murison, Alexander, Aronson, Lauren I., Wardell, Christopher P., Thompson, Andrew J., Hanrahan, Sarah J., Fok, Jacqueline H. L., Pawlyn, Charlotte, Kaiser, Martin F., Walker, Brian A., Davies, Faith E., Morgan, Gareth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055699/
https://www.ncbi.nlm.nih.gov/pubmed/24923560
http://dx.doi.org/10.1371/journal.pone.0099493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055699/
https://www.ncbi.nlm.nih.gov/pubmed/24923560
http://dx.doi.org/10.1371/journal.pone.0099493

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