A Synthetic Manassantin A Derivative Inhibits Hypoxia-Inducible Factor 1 and Tumor Growth

The dineolignan manassantin A from Saururaceae was recently identified as a hypoxia-inducible factor 1 (HIF-1) inhibitor, but its in-vivo anti-tumor effect has not been explored. We synthesized a series of manassantin A derivatives, and found that replacing the central tetrahydrofuran moiety with a...

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Detalles Bibliográficos
Autores principales: Lang, Liwei, Liu, Xiaoyu, Li, Yan, Zhou, Qing, Xie, Ping, Yan, Chunhong, Chen, Xiaoguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055733/
https://www.ncbi.nlm.nih.gov/pubmed/24925080
http://dx.doi.org/10.1371/journal.pone.0099584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055733/
https://www.ncbi.nlm.nih.gov/pubmed/24925080
http://dx.doi.org/10.1371/journal.pone.0099584

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