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The Glycosylated Rv1860 Protein of Mycobacterium tuberculosis Inhibits Dendritic Cell Mediated TH1 and TH17 Polarization of T Cells and Abrogates Protective Immunity Conferred by BCG
We previously reported interferon gamma secretion by human CD4(+) and CD8(+) T cells in response to recombinant E. coli-expressed Rv1860 protein of Mycobacterium tuberculosis (MTB) as well as protection of guinea pigs against a challenge with virulent MTB following prime-boost immunization with DNA...
Autores principales: | Satchidanandam, Vijaya, Kumar, Naveen, Jumani, Rajiv S., Challu, Vijay, Elangovan, Shobha, Khan, Naseem A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055742/ https://www.ncbi.nlm.nih.gov/pubmed/24945624 http://dx.doi.org/10.1371/journal.ppat.1004176 |
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