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The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer
Controversy remains regarding the effect of obesity on the survival of patients with ovarian cancer in Asia. This study examined the impact of obesity on the survival outcomes in advanced epithelial ovarian cancer (EOC) using Asian body mass index (BMI) criteria. The medical records of patients unde...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055812/ https://www.ncbi.nlm.nih.gov/pubmed/24932080 http://dx.doi.org/10.3346/jkms.2014.29.6.793 |
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author | Bae, Hyo Sook Hong, Jin Hwa Ki, Kyoung-Do Song, Jae Yun Shin, Jin Woo Lee, Jong Min Lee, Jae Kwan Lee, Nak Woo Lee, Chan Lee, Kyu Wan Kim, Yong Min |
author_facet | Bae, Hyo Sook Hong, Jin Hwa Ki, Kyoung-Do Song, Jae Yun Shin, Jin Woo Lee, Jong Min Lee, Jae Kwan Lee, Nak Woo Lee, Chan Lee, Kyu Wan Kim, Yong Min |
author_sort | Bae, Hyo Sook |
collection | PubMed |
description | Controversy remains regarding the effect of obesity on the survival of patients with ovarian cancer in Asia. This study examined the impact of obesity on the survival outcomes in advanced epithelial ovarian cancer (EOC) using Asian body mass index (BMI) criteria. The medical records of patients undergoing surgery for advanced (stage III and IV) EOC were reviewed. Statistical analyses included ANOVA, chi-square test, Kaplan-Meier survival and Cox regression analysis. Among all 236 patients, there were no differences in overall survival according to BMI except in underweight patients. In a multivariate Cox analysis, surgical optimality and underweight status were independent and significant prognostic factors for survival (HR, 2.302; 95% CI, 1.326-3.995; P=0.003 and HR, 8.622; 95% CI, 1.871-39.737; P = 0.006, respectively). In the subgroup of serous histology and optimal surgery, overweight and obese I patients showed better survival than normal weight patients (P = 0.012). We found that underweight BMI and surgical optimality are independent risk factors for the survival of patients with advanced ovarian cancer. High BMI groups (overweight, obese I and II) are not associated with the survival of advanced EOC patient. However, in the subgroup of EOC patients with serous histology and after optimal operation, overweight and obese I group patients show better survival than the normal weight group patients. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-4055812 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-40558122014-06-15 The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer Bae, Hyo Sook Hong, Jin Hwa Ki, Kyoung-Do Song, Jae Yun Shin, Jin Woo Lee, Jong Min Lee, Jae Kwan Lee, Nak Woo Lee, Chan Lee, Kyu Wan Kim, Yong Min J Korean Med Sci Original Article Controversy remains regarding the effect of obesity on the survival of patients with ovarian cancer in Asia. This study examined the impact of obesity on the survival outcomes in advanced epithelial ovarian cancer (EOC) using Asian body mass index (BMI) criteria. The medical records of patients undergoing surgery for advanced (stage III and IV) EOC were reviewed. Statistical analyses included ANOVA, chi-square test, Kaplan-Meier survival and Cox regression analysis. Among all 236 patients, there were no differences in overall survival according to BMI except in underweight patients. In a multivariate Cox analysis, surgical optimality and underweight status were independent and significant prognostic factors for survival (HR, 2.302; 95% CI, 1.326-3.995; P=0.003 and HR, 8.622; 95% CI, 1.871-39.737; P = 0.006, respectively). In the subgroup of serous histology and optimal surgery, overweight and obese I patients showed better survival than normal weight patients (P = 0.012). We found that underweight BMI and surgical optimality are independent risk factors for the survival of patients with advanced ovarian cancer. High BMI groups (overweight, obese I and II) are not associated with the survival of advanced EOC patient. However, in the subgroup of EOC patients with serous histology and after optimal operation, overweight and obese I group patients show better survival than the normal weight group patients. GRAPHICAL ABSTRACT: [Image: see text] The Korean Academy of Medical Sciences 2014-06 2014-05-30 /pmc/articles/PMC4055812/ /pubmed/24932080 http://dx.doi.org/10.3346/jkms.2014.29.6.793 Text en © 2014 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Bae, Hyo Sook Hong, Jin Hwa Ki, Kyoung-Do Song, Jae Yun Shin, Jin Woo Lee, Jong Min Lee, Jae Kwan Lee, Nak Woo Lee, Chan Lee, Kyu Wan Kim, Yong Min The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer |
title | The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer |
title_full | The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer |
title_fullStr | The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer |
title_full_unstemmed | The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer |
title_short | The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer |
title_sort | effect of body mass index on survival in advanced epithelial ovarian cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055812/ https://www.ncbi.nlm.nih.gov/pubmed/24932080 http://dx.doi.org/10.3346/jkms.2014.29.6.793 |
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