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The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer

Controversy remains regarding the effect of obesity on the survival of patients with ovarian cancer in Asia. This study examined the impact of obesity on the survival outcomes in advanced epithelial ovarian cancer (EOC) using Asian body mass index (BMI) criteria. The medical records of patients unde...

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Autores principales: Bae, Hyo Sook, Hong, Jin Hwa, Ki, Kyoung-Do, Song, Jae Yun, Shin, Jin Woo, Lee, Jong Min, Lee, Jae Kwan, Lee, Nak Woo, Lee, Chan, Lee, Kyu Wan, Kim, Yong Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055812/
https://www.ncbi.nlm.nih.gov/pubmed/24932080
http://dx.doi.org/10.3346/jkms.2014.29.6.793
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author Bae, Hyo Sook
Hong, Jin Hwa
Ki, Kyoung-Do
Song, Jae Yun
Shin, Jin Woo
Lee, Jong Min
Lee, Jae Kwan
Lee, Nak Woo
Lee, Chan
Lee, Kyu Wan
Kim, Yong Min
author_facet Bae, Hyo Sook
Hong, Jin Hwa
Ki, Kyoung-Do
Song, Jae Yun
Shin, Jin Woo
Lee, Jong Min
Lee, Jae Kwan
Lee, Nak Woo
Lee, Chan
Lee, Kyu Wan
Kim, Yong Min
author_sort Bae, Hyo Sook
collection PubMed
description Controversy remains regarding the effect of obesity on the survival of patients with ovarian cancer in Asia. This study examined the impact of obesity on the survival outcomes in advanced epithelial ovarian cancer (EOC) using Asian body mass index (BMI) criteria. The medical records of patients undergoing surgery for advanced (stage III and IV) EOC were reviewed. Statistical analyses included ANOVA, chi-square test, Kaplan-Meier survival and Cox regression analysis. Among all 236 patients, there were no differences in overall survival according to BMI except in underweight patients. In a multivariate Cox analysis, surgical optimality and underweight status were independent and significant prognostic factors for survival (HR, 2.302; 95% CI, 1.326-3.995; P=0.003 and HR, 8.622; 95% CI, 1.871-39.737; P = 0.006, respectively). In the subgroup of serous histology and optimal surgery, overweight and obese I patients showed better survival than normal weight patients (P = 0.012). We found that underweight BMI and surgical optimality are independent risk factors for the survival of patients with advanced ovarian cancer. High BMI groups (overweight, obese I and II) are not associated with the survival of advanced EOC patient. However, in the subgroup of EOC patients with serous histology and after optimal operation, overweight and obese I group patients show better survival than the normal weight group patients. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-40558122014-06-15 The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer Bae, Hyo Sook Hong, Jin Hwa Ki, Kyoung-Do Song, Jae Yun Shin, Jin Woo Lee, Jong Min Lee, Jae Kwan Lee, Nak Woo Lee, Chan Lee, Kyu Wan Kim, Yong Min J Korean Med Sci Original Article Controversy remains regarding the effect of obesity on the survival of patients with ovarian cancer in Asia. This study examined the impact of obesity on the survival outcomes in advanced epithelial ovarian cancer (EOC) using Asian body mass index (BMI) criteria. The medical records of patients undergoing surgery for advanced (stage III and IV) EOC were reviewed. Statistical analyses included ANOVA, chi-square test, Kaplan-Meier survival and Cox regression analysis. Among all 236 patients, there were no differences in overall survival according to BMI except in underweight patients. In a multivariate Cox analysis, surgical optimality and underweight status were independent and significant prognostic factors for survival (HR, 2.302; 95% CI, 1.326-3.995; P=0.003 and HR, 8.622; 95% CI, 1.871-39.737; P = 0.006, respectively). In the subgroup of serous histology and optimal surgery, overweight and obese I patients showed better survival than normal weight patients (P = 0.012). We found that underweight BMI and surgical optimality are independent risk factors for the survival of patients with advanced ovarian cancer. High BMI groups (overweight, obese I and II) are not associated with the survival of advanced EOC patient. However, in the subgroup of EOC patients with serous histology and after optimal operation, overweight and obese I group patients show better survival than the normal weight group patients. GRAPHICAL ABSTRACT: [Image: see text] The Korean Academy of Medical Sciences 2014-06 2014-05-30 /pmc/articles/PMC4055812/ /pubmed/24932080 http://dx.doi.org/10.3346/jkms.2014.29.6.793 Text en © 2014 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Bae, Hyo Sook
Hong, Jin Hwa
Ki, Kyoung-Do
Song, Jae Yun
Shin, Jin Woo
Lee, Jong Min
Lee, Jae Kwan
Lee, Nak Woo
Lee, Chan
Lee, Kyu Wan
Kim, Yong Min
The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer
title The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer
title_full The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer
title_fullStr The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer
title_full_unstemmed The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer
title_short The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer
title_sort effect of body mass index on survival in advanced epithelial ovarian cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055812/
https://www.ncbi.nlm.nih.gov/pubmed/24932080
http://dx.doi.org/10.3346/jkms.2014.29.6.793
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