Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation

The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development and progression of cancer; however, therapeutics targeting it have had disappointing results in the clinic. As a receptor tyrosine kinase (RTK), IGF-1R is traditionally described as an ON/OFF system, with lig...

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Detalles Bibliográficos
Autores principales: Girnita, Leonard, Worrall, Claire, Takahashi, Shin-Ichiro, Seregard, Stefan, Girnita, Ada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Basel 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055838/
https://www.ncbi.nlm.nih.gov/pubmed/24276851
http://dx.doi.org/10.1007/s00018-013-1514-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055838/
https://www.ncbi.nlm.nih.gov/pubmed/24276851
http://dx.doi.org/10.1007/s00018-013-1514-y

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