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Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells
BACKGROUND: Metastatic triple-negative breast cancer is mostly incurable, due to lack of suitable drug targets. The insulin-like growth factor (IGF) system could provide such a target, and IGF-1 receptor (IGF-1R)-directed agents are already available, but seem unable to control all the complexities...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056066/ https://www.ncbi.nlm.nih.gov/pubmed/24853185 http://dx.doi.org/10.1038/bjc.2014.269 |