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Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells

BACKGROUND: Metastatic triple-negative breast cancer is mostly incurable, due to lack of suitable drug targets. The insulin-like growth factor (IGF) system could provide such a target, and IGF-1 receptor (IGF-1R)-directed agents are already available, but seem unable to control all the complexities...

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Detalles Bibliográficos
Autores principales:	Mancini, M, Gariboldi, M B, Taiana, E, Bonzi, M C, Craparotta, I, Pagin, M, Monti, E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056066/ https://www.ncbi.nlm.nih.gov/pubmed/24853185 http://dx.doi.org/10.1038/bjc.2014.269

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