CamKII inhibitors reduce mitotic instability, connexon anomalies and progression of the in vivo behavioral phenotype in transgenic animals expressing a mutated Gjb1 gene

Mutation in the Gjb1 gene, coding for a connexin (Cx32), is associated with an inherited peripheral neuropathic disorder (X-linked Charcot-Marie-Tooth, CMTX). Our previous work reported that transgenic animals expressing a human Gjb1 transgene present polyploidy and abnormal over-duplication of the...

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Detalles Bibliográficos
Autores principales: Mones, Saleh, Bordignon, Benoit, Peiretti, Franck, Landrier, Jean F., Gess, Burkhardt, Bourguignon, Jean J., Bihel, Frédéric, Fontés, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056282/
https://www.ncbi.nlm.nih.gov/pubmed/24982612
http://dx.doi.org/10.3389/fnins.2014.00151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056282/
https://www.ncbi.nlm.nih.gov/pubmed/24982612
http://dx.doi.org/10.3389/fnins.2014.00151

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