Incretin Receptor Null Mice Reveal Key Role of GLP-1 but Not GIP in Pancreatic Beta Cell Adaptation to Pregnancy

Islet adaptations to pregnancy were explored in C57BL6/J mice lacking functional receptors for glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP). Pregnant wild type mice and GIPRKO mice exhibited marked increases in islet and beta cell area, numbers of medium/large sized islet...

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Detalles Bibliográficos
Autores principales: Moffett, R. Charlotte, Vasu, Srividya, Thorens, Bernard, Drucker, Daniel J., Flatt, Peter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057070/
https://www.ncbi.nlm.nih.gov/pubmed/24927416
http://dx.doi.org/10.1371/journal.pone.0096863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057070/
https://www.ncbi.nlm.nih.gov/pubmed/24927416
http://dx.doi.org/10.1371/journal.pone.0096863

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