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HMGB1 as a drug target in staphylococcal pneumonia

High mobility group box (HMGB)1 is a small DNA-binding protein. In the nucleus, HMGB1 plays a role in gene expression and DNA replication. When it is released or secreted into the extracellular milieu, HMGB1 functions as a pro-inflammatory cytokine-like mediator. Recently reported data support the v...

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Detalles Bibliográficos
Autor principal: Fink, Mitchell P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057072/
https://www.ncbi.nlm.nih.gov/pubmed/25029244
http://dx.doi.org/10.1186/cc13810