Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment

Adaptive cellular responses resulting from multiple microenvironmental stresses, such as hypoxia and nutrient deprivation, are potential novel drug targets for cancer treatment. Accordingly, we focused on developing anticancer agents targeting the tumor microenvironment (TME). In this study, to sear...

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Detalles Bibliográficos
Autores principales: Narise, Kosuke, Okuda, Kensuke, Enomoto, Yukihiro, Hirayama, Tasuku, Nagasawa, Hideko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057329/
https://www.ncbi.nlm.nih.gov/pubmed/24944508
http://dx.doi.org/10.2147/DDDT.S59679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057329/
https://www.ncbi.nlm.nih.gov/pubmed/24944508
http://dx.doi.org/10.2147/DDDT.S59679

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