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Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment
Adaptive cellular responses resulting from multiple microenvironmental stresses, such as hypoxia and nutrient deprivation, are potential novel drug targets for cancer treatment. Accordingly, we focused on developing anticancer agents targeting the tumor microenvironment (TME). In this study, to sear...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057329/ https://www.ncbi.nlm.nih.gov/pubmed/24944508 http://dx.doi.org/10.2147/DDDT.S59679 |