Effect of MRE11 Loss on PARP-Inhibitor Sensitivity in Endometrial Cancer In Vitro

AIM OF THE STUDY: To evaluate the frequency of MRE11/RAD50/NBS1 (MRN)-complex loss of protein expression in endometrial cancers (EC) and to determine whether loss of MRE11 renders the cancer cells sensitive to Poly(ADP-ribose) polymerase (PARP)-inhibitory treatment. METHODS: MRN expression was exami...

Descripción completa

Detalles Bibliográficos
Autores principales: Koppensteiner, Romana, Samartzis, Eleftherios P., Noske, Aurelia, von Teichman, Adriana, Dedes, Ioannis, Gwerder, Myriam, Imesch, Patrick, Ikenberg, Kristian, Moch, Holger, Fink, Daniel, Stucki, Manuel, Dedes, Konstantin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057395/
https://www.ncbi.nlm.nih.gov/pubmed/24927325
http://dx.doi.org/10.1371/journal.pone.0100041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057395/
https://www.ncbi.nlm.nih.gov/pubmed/24927325
http://dx.doi.org/10.1371/journal.pone.0100041

Ejemplares similares