A framework for application of metabolic modeling in yeast to predict the effects of nsSNV in human orthologs

BACKGROUND: We have previously suggested a method for proteome wide analysis of variation at functional residues wherein we identified the set of all human genes with nonsynonymous single nucleotide variation (nsSNV) in the active site residue of the corresponding proteins. 34 of these proteins were...

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Detalles Bibliográficos
Autores principales: Dingerdissen, Hayley, Weaver, Daniel S, Karp, Peter D, Pan, Yang, Simonyan, Vahan, Mazumder, Raja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057618/
https://www.ncbi.nlm.nih.gov/pubmed/24894379
http://dx.doi.org/10.1186/1745-6150-9-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057618/
https://www.ncbi.nlm.nih.gov/pubmed/24894379
http://dx.doi.org/10.1186/1745-6150-9-9

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