Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues

A series of caffeic acid amides were designed, synthesized and evaluated for anti-inflammatory activity. Most of them exhibited promising anti-inflammatory activity against nitric oxide (NO) generation in murine macrophage RAW264.7 cells. A 3D pharmacophore model was created based on the biological...

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Detalles Bibliográficos
Autores principales: Liu, Zhiqian, Fu, Jianjun, Shan, Lei, Sun, Qingyan, Zhang, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057760/
https://www.ncbi.nlm.nih.gov/pubmed/24857914
http://dx.doi.org/10.3390/ijms15058808
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author Liu, Zhiqian
Fu, Jianjun
Shan, Lei
Sun, Qingyan
Zhang, Weidong
author_facet Liu, Zhiqian
Fu, Jianjun
Shan, Lei
Sun, Qingyan
Zhang, Weidong
author_sort Liu, Zhiqian
collection PubMed
description A series of caffeic acid amides were designed, synthesized and evaluated for anti-inflammatory activity. Most of them exhibited promising anti-inflammatory activity against nitric oxide (NO) generation in murine macrophage RAW264.7 cells. A 3D pharmacophore model was created based on the biological results for further structural optimization. Moreover, predication of the potential targets was also carried out by the PharmMapper server. These amide analogues represent a promising class of anti-inflammatory scaffold for further exploration and target identification.
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spelling pubmed-40577602014-06-16 Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues Liu, Zhiqian Fu, Jianjun Shan, Lei Sun, Qingyan Zhang, Weidong Int J Mol Sci Communication A series of caffeic acid amides were designed, synthesized and evaluated for anti-inflammatory activity. Most of them exhibited promising anti-inflammatory activity against nitric oxide (NO) generation in murine macrophage RAW264.7 cells. A 3D pharmacophore model was created based on the biological results for further structural optimization. Moreover, predication of the potential targets was also carried out by the PharmMapper server. These amide analogues represent a promising class of anti-inflammatory scaffold for further exploration and target identification. Molecular Diversity Preservation International (MDPI) 2014-05-16 /pmc/articles/PMC4057760/ /pubmed/24857914 http://dx.doi.org/10.3390/ijms15058808 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Liu, Zhiqian
Fu, Jianjun
Shan, Lei
Sun, Qingyan
Zhang, Weidong
Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues
title Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues
title_full Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues
title_fullStr Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues
title_full_unstemmed Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues
title_short Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues
title_sort synthesis, preliminary bioevaluation and computational analysis of caffeic acid analogues
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057760/
https://www.ncbi.nlm.nih.gov/pubmed/24857914
http://dx.doi.org/10.3390/ijms15058808
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AT sunqingyan synthesispreliminarybioevaluationandcomputationalanalysisofcaffeicacidanalogues
AT zhangweidong synthesispreliminarybioevaluationandcomputationalanalysisofcaffeicacidanalogues

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