Mycobacterium tuberculosis expressing phospholipase C subverts PGE(2) synthesis and induces necrosis in alveolar macrophages

BACKGROUND: Phospholipases C (PLCs) are virulence factors found in several bacteria. In Mycobacterium tuberculosis (Mtb) they exhibit cytotoxic effects on macrophages, but the mechanisms involved in PLC-induced cell death are not fully understood. It has been reported that induction of cell necrosis...

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Detalles Bibliográficos
Autores principales: Assis, Patricia A, Espíndola, Milena S, Paula-Silva, Francisco WG, Rios, Wendy M, Pereira, Priscilla AT, Leão, Sylvia C, Silva, Célio L, Faccioli, Lúcia H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057917/
https://www.ncbi.nlm.nih.gov/pubmed/24886263
http://dx.doi.org/10.1186/1471-2180-14-128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057917/
https://www.ncbi.nlm.nih.gov/pubmed/24886263
http://dx.doi.org/10.1186/1471-2180-14-128

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