Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma

The tumor suppressor p53 and its signaling pathway play a critical role in tumor prevention. As a direct p53 target gene, the role of glutaminase 2 (GLS2) in tumorigenesis is unclear. In this study, we found that GLS2 expression is significantly decreased in majority of human hepatocellular carcinom...

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Detalles Bibliográficos
Autores principales: Liu, Juan, Zhang, Cen, Lin, Meihua, Zhu, Wei, Liang, Yingjian, Hong, Xuehui, Zhao, Yuhan, Young, Ken H., Hu, Wenwei, Feng, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058033/
https://www.ncbi.nlm.nih.gov/pubmed/24797434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058033/
https://www.ncbi.nlm.nih.gov/pubmed/24797434

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