The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway

The activation of apoptotic pathways results in the caspase cleavage of the Lyn tyrosine kinase to generate the N-terminal truncated LynΔN. This LynΔN fragment has been demonstrated to exert negative feedback on imatinib induced apoptosis in chronic myelogenous leukemia (CML) K562 cells. Our investi...

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Detalles Bibliográficos
Autores principales: Eldeeb, Mohamed A., Fahlman, Richard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058039/
https://www.ncbi.nlm.nih.gov/pubmed/24798867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058039/
https://www.ncbi.nlm.nih.gov/pubmed/24798867

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