Low dose tubulin-binding drugs rescue peroxisome trafficking deficit in patient-derived stem cells in Hereditary Spastic Paraplegia

Hereditary Spastic Paraplegia (HSP) is a genetically heterogeneous group of disorders, diagnosed by progressive gait disturbances with muscle weakness and spasticity, for which there are no treatments targeted at the underlying pathophysiology. Mutations in spastin are a common cause of HSP. Spastin...

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Detalles Bibliográficos
Autores principales: Fan, Yongjun, Wali, Gautam, Sutharsan, Ratneswary, Bellette, Bernadette, Crane, Denis I., Sue, Carolyn M., Mackay-Sim, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058084/
https://www.ncbi.nlm.nih.gov/pubmed/24857849
http://dx.doi.org/10.1242/bio.20147641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058084/
https://www.ncbi.nlm.nih.gov/pubmed/24857849
http://dx.doi.org/10.1242/bio.20147641

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