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Target Profile Prediction and Practical Evaluation of a Biginelli-Type Dihydropyrimidine Compound Library

We present a self-organizing map (SOM) approach to predicting macromolecular targets for combinatorial compound libraries. The aim was to study the usefulness of the SOM in combination with a topological pharmacophore representation (CATS) for selecting biologically active compounds from a virtual c...

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Detalles Bibliográficos
Autores principales: Schneider, Petra, Stutz, Katharina, Kasper, Ladina, Haller, Sarah, Reutlinger, Michael, Reisen, Felix, Geppert, Tim, Schneider, Gisbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058656/
http://dx.doi.org/10.3390/ph4091236