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A combinatorial approach for analyzing intra-tumor heterogeneity from high-throughput sequencing data

Motivation: High-throughput sequencing of tumor samples has shown that most tumors exhibit extensive intra-tumor heterogeneity, with multiple subpopulations of tumor cells containing different somatic mutations. Recent studies have quantified this intra-tumor heterogeneity by clustering mutations in...

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Detalles Bibliográficos
Autores principales: Hajirasouliha, Iman, Mahmoody, Ahmad, Raphael, Benjamin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058927/
https://www.ncbi.nlm.nih.gov/pubmed/24932008
http://dx.doi.org/10.1093/bioinformatics/btu284