Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release

Augmentation of immunogenicity can be achieved by particulate delivery of an antigen and by its co-administration with an adjuvant. However, many adjuvants initiate strong systemic inflammatory reactions in vivo, leading to potential adverse events and safety concerns. We have developed a synthetic...

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Detalles Bibliográficos
Autores principales: Ilyinskii, Petr O., Roy, Christopher J., O’Neil, Conlin P., Browning, Erica A., Pittet, Lynnelle A., Altreuter, David H., Alexis, Frank, Tonti, Elena, Shi, Jinjun, Basto, Pamela A., Iannacone, Matteo, Radovic-Moreno, Aleksandar F., Langer, Robert S., Farokhzad, Omid C., von Andrian, Ulrich H., Johnston, Lloyd P.M., Kishimoto, Takashi Kei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059049/
https://www.ncbi.nlm.nih.gov/pubmed/24593999
http://dx.doi.org/10.1016/j.vaccine.2014.02.027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059049/
https://www.ncbi.nlm.nih.gov/pubmed/24593999
http://dx.doi.org/10.1016/j.vaccine.2014.02.027

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