Cargando…

Influence of antiTNF-alpha antibody treatment on fracture healing under chronic inflammation

BACKGROUND: The overexpression of tumor necrosis factor (TNF)-α leads to systemic as well as local loss of bone and cartilage and is also an important regulator during fracture healing. In this study, we investigate how TNF-α inhibition using a targeted monoclonal antibody affects fracture healing i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Timmen, Melanie, Hidding, Heriburg, Wieskötter, Britta, Baum, Wolfgang, Pap, Thomas, Raschke, Michael J, Schett, Georg, Zwerina, Jochen, Stange, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059090/ https://www.ncbi.nlm.nih.gov/pubmed/24885217 http://dx.doi.org/10.1186/1471-2474-15-184

Ejemplares similares

The heparan sulfate proteoglycan Syndecan-1 influences local bone cell communication via the RANKL/OPG axis
por: Timmen, Melanie, et al.
Publicado: (2020)

AntiTNF-alpha therapy normalizes levels of lipids and adipokines in psoriatic patients in the real-life settings
por: Olejniczak-Staruch, Irmina, et al.
Publicado: (2021)

Anakinra in systemic juvenile idiopathic arthritis (soJIA) non responsive to antiTNF
por: Pontikaki, I, et al.
Publicado: (2008)

Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing
por: Sivaraj, Kishor K., et al.
Publicado: (2022)

A novel MRI compatible mouse fracture model to characterize and monitor bone regeneration and tissue composition
por: Schmitz, Nina, et al.
Publicado: (2020)

Münsteraner Fahrradunfälle im Wandel der Zeit: Analyse der Entwicklung der Fahrradunfälle in den letzten 10 Jahren
por: Schlautmann, Désirée, et al.
Publicado: (2023)

Fra-1 regulates inflammatory and degenerative arthritis
por: Kireva, T, et al.
Publicado: (2010)

Overexpression of TNF causes bilateral sacroiliitis
por: Redlich, K, et al.
Publicado: (2004)

Imbalance of local bone metabolism in inflammatory arthritis and its reversal upon tumor necrosis factor blockade: direct analysis of bone turnover in murine arthritis
por: Zwerina, Jochen, et al.
Publicado: (2006)

Microsurgical reconstruction affects the outcome in a translational mouse model for Achilles tendon healing
por: Michel, Philipp A., et al.
Publicado: (2020)

Isolated and combined inhibition of TNF-, IL-1 and RANKL-pathways in TNF-induced arthritis: effects on synovial inflammation, bone erosion and cartilage destruction
por: Zwerina, J, et al.
Publicado: (2003)

Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-TNF in combination with OPG or PTH in TNF-mediated arthritis
por: Redlich, K, et al.
Publicado: (2004)

Tumour necrosis factor activates the mitogen-activated protein kinases p38α and ERK in the synovial membrane in vivo
por: Görtz, Birgit, et al.
Publicado: (2005)

TNF and IL-6 differentially regulate the production of DKK-1, a master regulator of bone remodelling, by fibroblast-like synoviocytes
por: Yeremenko, N, et al.
Publicado: (2010)

Osteoclasts are essential for TNF-mediated joint destruction
por: Redlich, KR, et al.
Publicado: (2002)

Osteoprotegerin protects from generalized bone loss in TNF-transgenic mice
por: Hayer, S, et al.
Publicado: (2003)

Zoledronic acid protects from local and systemic bone loss in TNF-mediated arthritis
por: Zwerina, J, et al.
Publicado: (2004)

Lack of inhibitory effects of the anti-fibrotic drug imatinib on endothelial cell functions in vitro and in vivo
por: Venalis, Paulius, et al.
Publicado: (2009)

Comparative Analysis of TNF-alpha, TNF-R1, and TNF-R2 in Patients with Low-impact Fractures Due to Osteoporosis
por: Teixeira, Abel Oliveira Marques, et al.
Publicado: (2023)

Higher dose but not low dose proton pump inhibitors are associated with increased risk of subsequent hip fractures after first hip fracture: A nationwide observational cohort study
por: Brozek, Wolfgang, et al.
Publicado: (2019)

Central nervous system effects of tumor necrosis factor alpha blockade
por: Schett, Georg
Publicado: (2011)

Microparticles stimulate angiogenesis by inducing ELR(+) CXC-chemokines in synovial fibroblasts
por: Reich, Nicole, et al.
Publicado: (2011)

Influence of the Peripheral Nervous System on Murine Osteoporotic Fracture Healing and Fracture-Induced Hyperalgesia
por: Wank, Isabel, et al.
Publicado: (2022)

Rate and Predictors of Mucosal Healing in Patients with Inflammatory Bowel Disease Treated with Anti-TNF-Alpha Antibodies
por: Beigel, Florian, et al.
Publicado: (2014)

Design of the Tocilizumab in Giant Cell Arteritis Trial
por: Unizony, Sebastian H., et al.
Publicado: (2013)

Re-exposure with a TNF inhibitor bio-similar was well tolerated and led to sustained control of psoriatic arthritis after allergic reaction to the TNF inhibitor bio-originator
por: Valor-Méndez, Larissa, et al.
Publicado: (2022)

Adenoviral-based overexpression of TIMP-1 reduces tissue damage in the joints of TNF-alpha transgenic mice
por: Schett, G, et al.
Publicado: (2001)

Identifying adult hypophosphatasia in the rheumatology unit
por: Feurstein, Julia, et al.
Publicado: (2022)

Pelvic Fractures—An Underestimated Problem? Incidence and Mortality Risk after Pelvic Fracture in Austria, 2010–2018
por: Behanova, Martina, et al.
Publicado: (2022)

Upper zone of growth plate and cartilage matrix associated protein protects cartilage during inflammatory arthritis
por: Seuffert, Fritz, et al.
Publicado: (2018)

Efficiency of Orexin-A for Inflammatory Flare and Mucosal Healing in Experimental Colitis: Comparison with the Anti-TNF Alpha Infliximab
por: Blais, Anne, et al.
Publicado: (2023)

Scapholunate ligament reconstruction using a part of the extensor carpi radialis brevis tendon through a dorsal approach
por: Oeckenpöhler, Simon, et al.
Publicado: (2023)

Anti-TNF-alpha-induced lupus
por: De Bandt, Michel
Publicado: (2019)

Stimulation of fibroblast chemotaxis by human recombinant tumor necrosis factor alpha (TNF-alpha) and a synthetic TNF-alpha 31-68 peptide
Publicado: (1990)

Polymorphism of tumor necrosis factor alpha (TNF-alpha) gene promoter, circulating TNF-alpha level, and cardiovascular risk factor for ischemic stroke
por: Cui, Guanglin, et al.
Publicado: (2012)

The effects of alpha-tocopherol supplementation on fracture healing in a postmenopausal osteoporotic rat model
por: Mohamad, Sharlina, et al.
Publicado: (2012)

The Mitogen-Activated Protein Kinase p38α Regulates Tubular Damage in Murine Anti-Glomerular Basement Membrane Nephritis
por: Müller, Ralf, et al.
Publicado: (2013)

Liver and tumour tissue concentrations of TNF-alpha in cancer patients treated with TNF-alpha and melphalan by isolated liver perfusion.
por: Kuppen, P. J., et al.
Publicado: (1997)

Circulating TNF-Alpha and IL-6 Concentrations and TNF-Alpha -308 G > A Polymorphism in Children with Premature Adrenarche
por: Utriainen, Pauliina, et al.
Publicado: (2010)

Identification of the Schistosoma mansoni TNF-Alpha Receptor Gene and the Effect of Human TNF-Alpha on the Parasite Gene Expression Profile
por: Oliveira, Katia C., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_mgjm5261dd0vdlb05bq7vuli2l