Large-Scale, Protection-Free Synthesis of Se-Adenosyl-l-selenomethionine Analogues and Their Application as Cofactor Surrogates of Methyltransferases

[Image: see text] S-Adenosyl-l-methionine (SAM) analogues have previously demonstrated their utility as chemical reporters of methyltransferases. Here we describe the facile, large-scale synthesis of Se-alkyl Se-adenosyl-l-selenomethionine (SeAM) analogues and their precursor, Se-adenosyl-l-selenoho...

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Detalles Bibliográficos
Autores principales: Bothwell, Ian R., Luo, Minkui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059250/
https://www.ncbi.nlm.nih.gov/pubmed/24852128
http://dx.doi.org/10.1021/ol501169y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059250/
https://www.ncbi.nlm.nih.gov/pubmed/24852128
http://dx.doi.org/10.1021/ol501169y

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