Cargando…

Identification of an Atg8-Atg3 Protein–Protein Interaction Inhibitor from the Medicines for Malaria Venture Malaria Box Active in Blood and Liver Stage Plasmodium falciparum Parasites

[Image: see text] Atg8 is a ubiquitin-like autophagy protein in eukaryotes that is covalently attached (lipidated) to the elongating autophagosomal membrane. Autophagy is increasingly appreciated as a target in diverse diseases from cancer to eukaryotic parasitic infections. Some of the autophagy ma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hain, Adelaide U.P., Bartee, David, Sanders, Natalie G., Miller, Alexia S., Sullivan, David J., Levitskaya, Jelena, Meyers, Caren Freel, Bosch, Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059259/ https://www.ncbi.nlm.nih.gov/pubmed/24786226 http://dx.doi.org/10.1021/jm401675a

Ejemplares similares

Novel Antifungal Compounds Discovered in Medicines for Malaria Venture’s Malaria Box
por: Jung, Eric H., et al.
Publicado: (2018)

The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites
por: Looker, Oliver, et al.
Publicado: (2022)

Autophagy-Related Atg8 Localizes to the Apicoplast of the Human Malaria Parasite Plasmodium falciparum
por: Kitamura, Kei, et al.
Publicado: (2012)

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum Aminopeptidases, M1, M17 and M18
por: Paiardini, Alessandro, et al.
Publicado: (2015)

Targeted Phenotypic Screening in Plasmodium falciparum and Toxoplasma gondii Reveals Novel Modes of Action of Medicines for Malaria Venture Malaria Box Molecules
por: Subramanian, Gowtham, et al.
Publicado: (2018)

A Novel Piperazine-Based Drug Lead for Cryptosporidiosis from the Medicines for Malaria Venture Open-Access Malaria Box
por: Jumani, R. S., et al.
Publicado: (2018)

Screening the Medicines for Malaria Venture Pathogen Box against piroplasm parasites
por: Nugraha, Arifin Budiman, et al.
Publicado: (2019)

Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7–Atg3 and Atg7–Atg10 structures
por: Kaiser, Stephen E., et al.
Publicado: (2012)

Identifying a selective inhibitor of autophagy that targets ATG12-ATG3 protein-protein interaction
por: Nuta, Gal Chaim, et al.
Publicado: (2023)

Biological functions of the autophagy-related proteins Atg4 and Atg8 in Cryptococcus neoformans
por: Roberto, Thiago Nunes, et al.
Publicado: (2020)

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma
por: Hwang, Seungmin, et al.
Publicado: (2012)

Leveraging the Medicines for Malaria Venture malaria and pathogen boxes to discover chemical inhibitors of East Coast fever
por: Nyagwange, James, et al.
Publicado: (2019)

Atg7 in development and disease: panacea or Pandora’s Box?
por: Xiong, Jianhua
Publicado: (2015)

Different effects of Atg2 and Atg18 mutations on Atg8a and Atg9 trafficking during starvation in Drosophila()
por: Nagy, Péter, et al.
Publicado: (2014)

Increased Hepatic ATG7 mRNA and ATG7 Protein Expression in Nonalcoholic Steatohepatitis Associated with Obesity
por: Barrientos-Riosalido, Andrea, et al.
Publicado: (2023)

ATG Ubiquitination Is Required for Circumsporozoite Protein to Subvert Host Innate Immunity Against Rodent Malaria Liver Stage
por: Zheng, Hong, et al.
Publicado: (2022)

Closing the loop: Three musketeers of autophagy-ATG2, ATG18a, and ATG9
por: Mishra, Divya
Publicado: (2023)

Erratum for Subramanian et al., “Targeted Phenotypic Screening in Plasmodium falciparum and Toxoplasma gondii Reveals Novel Modes of Action of Medicines for Malaria Venture Malaria Box Molecules”
por: Subramanian, Gowtham, et al.
Publicado: (2019)

Crystallization of the Atg12–Atg5 conjugate bound to Atg16 by the free-interface diffusion method
por: Noda, Nobuo N., et al.
Publicado: (2008)

Leishmania donovani Growth Inhibitors from Pathogen Box Compounds of Medicine for Malaria Venture
por: Tadele, Markos, et al.
Publicado: (2020)

Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation
por: Sánchez-Wandelmer, Jana, et al.
Publicado: (2017)

Characterization of the Autophagy Marker Protein Atg8 Reveals Atypical Features of Autophagy in Plasmodium falciparum
por: Navale, Rahul, et al.
Publicado: (2014)

Activation and targeting of ATG8 protein lipidation
por: Martens, Sascha, et al.
Publicado: (2020)

Oxidation of Atg3 and Atg7 mediates inhibition of autophagy
por: Frudd, Karen, et al.
Publicado: (2018)

A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation
por: Li, Yi-Tong, et al.
Publicado: (2017)

Quantitative analysis of autophagy reveals the role of ATG9 and ATG2 in autophagosome formation
por: Broadbent, David G., et al.
Publicado: (2023)

Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni
por: Pasche, Valérian, et al.
Publicado: (2018)

Identification of Anti-staphylococcal and Anti-biofilm Compounds by Repurposing the Medicines for Malaria Venture Pathogen Box
por: Bhandari, Vasundhra, et al.
Publicado: (2018)

Atg3-Mediated Lipidation of Atg8 Is Involved in Encystation of Acanthamoeba
por: Moon, Eun-Kyung, et al.
Publicado: (2011)

Dual roles of Atg8−PE deconjugation by Atg4 in autophagy
por: Yu, Zhong-Qiu, et al.
Publicado: (2012)

Atg1 kinase organizes autophagosome formation by phosphorylating Atg9
por: Papinski, Daniel, et al.
Publicado: (2014)

Uba1 functions in Atg7- and Atg3-independent autophagy
por: Chang, Tsun-Kai, et al.
Publicado: (2013)

Atg11 tethers Atg9 vesicles to initiate selective autophagy
por: Matscheko, Nena, et al.
Publicado: (2019)

Association of ATG4B and Phosphorylated ATG4B Proteins with Tumorigenesis and Prognosis in Oral Squamous Cell Carcinoma
por: Liu, Pei-Feng, et al.
Publicado: (2019)

The autophagy-related proteins FvAtg4 and FvAtg8 are involved in virulence and fumonisin biosynthesis in Fusarium verticillioides
por: Wang, Yujie, et al.
Publicado: (2022)

PfATP4 inhibitors in the Medicines for Malaria Venture Malaria Box and Pathogen Box block the schizont-to-ring transition by inhibiting egress rather than invasion
por: Barnes, Claudia B. G., et al.
Publicado: (2022)

A nuclear role for Atg8-family proteins
por: Jacomin, Anne-Claire, et al.
Publicado: (2020)

Topology and Function of the S. cerevisiae Autophagy Protein Atg15
por: Marquardt, Lisa, et al.
Publicado: (2023)

The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions
por: Xiong, Qiuhong, et al.
Publicado: (2015)

Effect of ATG12–ATG5-ATG16L1 autophagy E3-like complex on the ability of LC3/GABARAP proteins to induce vesicle tethering and fusion
por: Iriondo, Marina N., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_k2mrskg8hqnc5u1q6himi9nfln