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Direct Activation of ATM by Resveratrol under Oxidizing Conditions

Resveratrol has been widely reported to reduce cancer progression in model systems and to selectively induce cell death in transformed cell lines. Many enzymes have been reported to respond to resveratrol in mammalian cells, including the Ataxia-Telangiectasia Mutated (ATM) protein kinase that acts...

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Detalles Bibliográficos
Autores principales: Lee, Ji-Hoon, Guo, Zhi, Myler, Logan R., Zheng, Suting, Paull, Tanya T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059639/
https://www.ncbi.nlm.nih.gov/pubmed/24933654
http://dx.doi.org/10.1371/journal.pone.0097969