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Chronic Treatment with Mood-Stabilizers Attenuates Abnormal Hyperlocomotion of GluA1-Subunit Deficient Mice

Abnormal excitatory glutamate neurotransmission and plasticity have been implicated in schizophrenia and affective disorders. Gria1−/− mice lacking GluA1 subunit (encoded by Gria1 gene) of AMPA-type glutamate receptor show robust novelty-induced hyperactivity, social deficits and heightened approach...

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Detalles Bibliográficos
Autores principales: Maksimovic, Milica, Vekovischeva, Olga Y., Aitta-aho, Teemu, Korpi, Esa R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059755/
https://www.ncbi.nlm.nih.gov/pubmed/24932798
http://dx.doi.org/10.1371/journal.pone.0100188