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Modulation of NCC activity by low and high K(+) intake: insights into the signaling pathways involved

Modulation of Na(+)-Cl(−) cotransporter (NCC) activity is essential to adjust K(+) excretion in the face of changes in dietary K(+) intake. We used previously characterized genetic mouse models to assess the role of Ste20-related proline-alanine-rich kinase (SPAK) and with-no-lysine kinase (WNK)4 in...

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Detalles Bibliográficos
Autores principales: Castañeda-Bueno, María, Cervantes-Perez, Luz Graciela, Rojas-Vega, Lorena, Arroyo-Garza, Isidora, Vázquez, Norma, Moreno, Erika, Gamba, Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059971/
https://www.ncbi.nlm.nih.gov/pubmed/24761002
http://dx.doi.org/10.1152/ajprenal.00255.2013