Improved Histone Deacetylase Inhibitors as Therapeutics for the Neurodegenerative Disease Friedreich's Ataxia: A New Synthetic Route

Friedreich's ataxia (FRDA) is caused by transcriptional repression of the nuclear FXN gene encoding the essential mitochondrial protein frataxin. Based on the hypothesis that the acetylation state of the histone proteins is responsible for gene silencing in FRDA, previous work in our lab identi...

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Detalles Bibliográficos
Autores principales: Xu, Chunping, Soragni, Elisabetta, Jacques, Vincent, Rusche, James R., Gottesfeld, Joel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060102/
https://www.ncbi.nlm.nih.gov/pubmed/27721337
http://dx.doi.org/10.3390/ph4121578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060102/
https://www.ncbi.nlm.nih.gov/pubmed/27721337
http://dx.doi.org/10.3390/ph4121578

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