Bosentan reverses the pro-fibrotic phenotype of systemic sclerosis dermal fibroblasts via increasing DNA binding ability of transcription factor Fli1

INTRODUCTION: Although the pathogenesis of systemic sclerosis (SSc) still remains unknown, recent studies have demonstrated that endothelins are deeply involved in the developmental process of fibrosis and vasculopathy associated with SSc, and a dual endothelin receptor antagonist, bosentan, has a p...

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Detalles Bibliográficos
Autores principales: Akamata, Kaname, Asano, Yoshihide, Aozasa, Naohiko, Noda, Shinji, Taniguchi, Takashi, Takahashi, Takehiro, Ichimura, Yohei, Toyama, Tetsuo, Sato, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060196/
https://www.ncbi.nlm.nih.gov/pubmed/24708674
http://dx.doi.org/10.1186/ar4529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060196/
https://www.ncbi.nlm.nih.gov/pubmed/24708674
http://dx.doi.org/10.1186/ar4529

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