Cargando…

Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis

Insulin signaling in the central nervous system (CNS) regulates energy balance and peripheral glucose homeostasis. Rictor is a key regulatory/structural subunit of the mTORC2 complex and is required for hydrophobic motif site phosphorylation of Akt at serine 473. To examine the contribution of neuro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kocalis, Heidi E., Hagan, Scott L., George, Leena, Turney, Maxine K., Siuta, Michael A., Laryea, Gloria N., Morris, Lindsey C., Muglia, Louis J., Printz, Richard L., Stanwood, Gregg D., Niswender, Kevin D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060224/ https://www.ncbi.nlm.nih.gov/pubmed/24944899 http://dx.doi.org/10.1016/j.molmet.2014.01.014

Ejemplares similares

Neuron-Specific Deletion of Peroxisome Proliferator-Activated Receptor Delta (PPARδ) in Mice Leads to Increased Susceptibility to Diet-Induced Obesity
por: Kocalis, Heidi E., et al.
Publicado: (2012)

Dysregulation of the Norepinephrine Transporter Sustains Cortical Hypodopaminergia and Schizophrenia-Like Behaviors in Neuronal Rictor Null Mice
por: Siuta, Michael A., et al.
Publicado: (2010)

Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors
por: Lee, Dongjun, et al.
Publicado: (2014)

Inhibition of mTORC2/RICTOR Impairs Melanoma Hepatic Metastasis()()
por: Schmidt, Katharina M., et al.
Publicado: (2018)

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan
por: Lamming, Dudley W, et al.
Publicado: (2014)

The mTORC2 Component Rictor Contributes to Cisplatin Resistance in Human Ovarian Cancer Cells
por: Im-aram, Akechai, et al.
Publicado: (2013)

Involvement of Rictor/mTORC2 in cardiomyocyte differentiation of mouse embryonic stem cells in vitro
por: Zheng, Bei, et al.
Publicado: (2017)

Inhibition of mTORC2 component RICTOR impairs tumor growth in pancreatic cancer models
por: Schmidt, Katharina M., et al.
Publicado: (2017)

microRNA-153 Targets mTORC2 Component Rictor to Inhibit Glioma Cells
por: Cui, Yan, et al.
Publicado: (2016)

TELO2 induced progression of colorectal cancer by binding with RICTOR through mTORC2
por: Guo, Zheng, et al.
Publicado: (2021)

Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology
por: Thomanetz, Venus, et al.
Publicado: (2013)

Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma
por: Benavides-Serrato, Angelica, et al.
Publicado: (2017)

PTH(1-34) activates the migration and adhesion of BMSCs through the rictor/mTORC2 pathway
por: Lv, Zhong, et al.
Publicado: (2020)

Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size
por: Gu, Yanyun, et al.
Publicado: (2011)

Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis
por: Li, Jianzhong, et al.
Publicado: (2015)

Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma
por: Benavides-Serrato, Angelica, et al.
Publicado: (2019)

The mTORC2 Component Rictor Is Required for Load‐Induced Bone Formation in Late‐Stage Skeletal Cells
por: Lewis, Karl J, et al.
Publicado: (2020)

Retraction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma
Publicado: (2023)

Mdm20 Modulates Actin Remodeling through the mTORC2 Pathway via Its Effect on Rictor Expression
por: Yasuda, Kunihiko, et al.
Publicado: (2015)

Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma
por: Akgül, Seçkin, et al.
Publicado: (2018)

RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma
por: Lu, Zhaoming, et al.
Publicado: (2020)

Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43
por: Wang, Jia-dan, et al.
Publicado: (2021)

Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss
por: Fu, Xiaolong, et al.
Publicado: (2022)

mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells
por: Chu, Qun, et al.
Publicado: (2022)

PTEN negatively regulates mTORC2 formation and signaling in grade IV glioma via Rictor hyperphosphorylation at Thr1135 and direct the mode of action of an mTORC1/2 inhibitor
por: Bhattacharya, K, et al.
Publicado: (2016)

The Deubiquitinase USP39 Promotes ESCC Tumorigenesis Through Pre-mRNA Splicing of the mTORC2 Component Rictor
por: Zhao, Yuan, et al.
Publicado: (2021)

Correction to: mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells
por: Chu, Qun, et al.
Publicado: (2022)

Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition
por: Ruicci, Kara M., et al.
Publicado: (2019)

mTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome
por: Rabanal-Ruiz, Yoana, et al.
Publicado: (2018)

Regulation of colonic epithelial cell homeostasis by mTORC1
por: Kotani, Takenori, et al.
Publicado: (2020)

Impaired mTORC2 signaling in catecholaminergic neurons exaggerates high fat diet-induced hyperphagia
por: Dadalko, Olga I., et al.
Publicado: (2015)

mTORC2/AKT/HSF1/HuR constitute a feed-forward loop regulating Rictor expression and tumor growth in glioblastoma
por: Holmes, Brent, et al.
Publicado: (2017)

Erratum to: Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition
por: Ruicci, Kara M., et al.
Publicado: (2019)

Fibroblast growth factor 1 ameliorates adipose tissue inflammation and systemic insulin resistance via enhancing adipocyte mTORC2/Rictor signal
por: Zhao, Longwei, et al.
Publicado: (2020)

Correction for Fu et al., Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss
Publicado: (2022)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cells
por: Sakai, Yusuke, et al.
Publicado: (2019)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_1o3eevh37h7ai58ngg09o63ogn