CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction

INTRODUCTION: NLRP3 plays a role in sensing various pathogen components or stresses in the innate immune system. Once activated, NLRP3 associates with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and procaspase-1 to form a large protein complex termed inflamm...

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Detalles Bibliográficos
Autores principales: Ito, Sayaka, Hara, Yukichi, Kubota, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060228/
https://www.ncbi.nlm.nih.gov/pubmed/24517500
http://dx.doi.org/10.1186/ar4483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060228/
https://www.ncbi.nlm.nih.gov/pubmed/24517500
http://dx.doi.org/10.1186/ar4483

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