Tumor Endothelium FasL Establishes a Selective Immune Barrier Promoting Tolerance in Tumors

We describe a novel mechanism regulating the tumor endothelial barrier and T cell homing to tumors. Selective expression of the death mediator Fas ligand (FasL/CD95L) was detected in the vasculature of many human and mouse solid tumors but not in normal vasculature, and in these tumors it was associ...

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Detalles Bibliográficos
Autores principales: Motz, Gregory T., Santoro, Stephen P., Wang, Li-Ping, Garrabrant, Tom, Lastra, Ricardo R., Hagemann, Ian S., Lal, Priti, Feldman, Michael D., Benencia, Fabian, Coukos, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060245/
https://www.ncbi.nlm.nih.gov/pubmed/24793239
http://dx.doi.org/10.1038/nm.3541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060245/
https://www.ncbi.nlm.nih.gov/pubmed/24793239
http://dx.doi.org/10.1038/nm.3541

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