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Adenosine A(2A )receptors promote collagen production by a Fli1- and CTGF-mediated mechanism

INTRODUCTION: Adenosine, acting through the A(2A )receptor, promotes tissue matrix production in the skin and the liver and induces the development of dermal fibrosis and cirrhosis in murine models. Since expression of A(2A )receptors is increased in scleroderma fibroblasts, we examined the mechanis...

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Detalles Bibliográficos
Autores principales: Chan, Edwin SL, Liu, Hailing, Fernandez, Patricia, Luna, Alex, Perez-Aso, Miguel, Bujor, Andreea M, Trojanowska, Maria, Cronstein, Bruce N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060252/
https://www.ncbi.nlm.nih.gov/pubmed/23663495
http://dx.doi.org/10.1186/ar4229