Silencing [Formula: see text] Rescues Tau Pathologies and Memory Deficits through Rescuing PP2A and Inhibiting GSK-3β Signaling in Human Tau Transgenic Mice

Increase of inhibitor-2 of protein phosphatase-2A [Formula: see text] is associated with protein phosphatase-2A (PP2A) inhibition and tau hyperphosphorylation in Alzheimer’s disease (AD). Down-regulating [Formula: see text] attenuated amyloidogenesis and improved the cognitive functions in transgeni...

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Detalles Bibliográficos
Autores principales: Zhang, Yao, Ma, Rong-Hong, Li, Xia-Chun, Zhang, Jia-Yu, Shi, Hai-Rong, Wei, Wei, Luo, Dan-Ju, Wang, Qun, Wang, Jian-Zhi, Liu, Gong-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060416/
https://www.ncbi.nlm.nih.gov/pubmed/24987368
http://dx.doi.org/10.3389/fnagi.2014.00123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060416/
https://www.ncbi.nlm.nih.gov/pubmed/24987368
http://dx.doi.org/10.3389/fnagi.2014.00123

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