Pharmacological Effects of JTT-551, a Novel Protein Tyrosine Phosphatase 1B Inhibitor, in Diet-Induced Obesity Mice

Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of leptin signaling as well as insulin signaling. JTT-551 is a new PTP1B inhibitor, which is reported to improve glucose metabolism by enhancement of insulin signaling. We have evaluated an antiobesity effect of JTT-551 using diet-induc...

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Detalles Bibliográficos
Autores principales: Ito, Makoto, Fukuda, Sumiaki, Sakata, Shohei, Morinaga, Hisayo, Ohta, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060493/
https://www.ncbi.nlm.nih.gov/pubmed/24987707
http://dx.doi.org/10.1155/2014/680348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060493/
https://www.ncbi.nlm.nih.gov/pubmed/24987707
http://dx.doi.org/10.1155/2014/680348

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