TERT Promoter Mutations Lead to High Transcriptional Activity under Hypoxia and Temozolomide Treatment and Predict Poor Prognosis in Gliomas

OBJECTIVE: This study explored the effects of telomerase reverse transcriptase (TERT) promoter mutations on transcriptional activity of the TERT gene under hypoxic and temozolomide (TMZ) treatment conditions, and investigated the status and prognostic value of these mutations in gliomas. METHODS: Th...

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Detalles Bibliográficos
Autores principales: Chen, Chen, Han, Sheng, Meng, Lingxuan, Li, Zhonghua, Zhang, Xue, Wu, Anhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061075/
https://www.ncbi.nlm.nih.gov/pubmed/24937153
http://dx.doi.org/10.1371/journal.pone.0100297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061075/
https://www.ncbi.nlm.nih.gov/pubmed/24937153
http://dx.doi.org/10.1371/journal.pone.0100297

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