Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts

BACKGROUND: Carbonic anhydrase IX (CA IX) is a transmembrane enzyme that is present in many types of solid tumors. Expression of CA IX is driven predominantly by the hypoxia-inducible factor (HIF) pathway and helps to maintain intracellular pH homeostasis under hypoxic conditions, resulting in acidi...

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Detalles Bibliográficos
Autores principales: Ditte, Zuzana, Ditte, Peter, Labudova, Martina, Simko, Veronika, Iuliano, Filippo, Zatovicova, Miriam, Csaderova, Lucia, Pastorekova, Silvia, Pastorek, Jaromir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061103/
https://www.ncbi.nlm.nih.gov/pubmed/24886661
http://dx.doi.org/10.1186/1471-2407-14-358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061103/
https://www.ncbi.nlm.nih.gov/pubmed/24886661
http://dx.doi.org/10.1186/1471-2407-14-358

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