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NMDA receptor- and ERK-dependent histone methylation changes in the lateral amygdala bidirectionally regulate fear memory formation

It is well established that fear memory formation requires de novo gene transcription in the amygdala. We provide evidence that epigenetic mechanisms in the form of histone lysine methylation in the lateral amygdala (LA) are regulated by NMDA receptor (NMDAR) signaling and involved in gene transcrip...

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Detalles Bibliográficos
Autores principales: Gupta-Agarwal, Swati, Jarome, Timothy J., Fernandez, Jordan, Lubin, Farah D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061426/
https://www.ncbi.nlm.nih.gov/pubmed/24939839
http://dx.doi.org/10.1101/lm.035105.114