Competitive HIF Prolyl Hydroxylase Inhibitors Show Protection against Oxidative Stress by a Mechanism Partially Dependent on Glycolysis

The hypoxia inducible factor 1 (HIF-1) is a central transcription factor involved in the cellular and molecular adaptation to hypoxia and low glucose supply. The level of HIF-1 is to a large degree regulated by the HIF prolyl hydroxylase enzymes (HPHs) belonging to the Fe(II) and 2-oxoglutarate-depe...

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Detalles Bibliográficos
Autores principales: Bergström, Ann-Louise, Fog, Karina, Sager, Thomas Nikolaj, Bruun, Anne Techau, Thirstrup, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061615/
https://www.ncbi.nlm.nih.gov/pubmed/25006572
http://dx.doi.org/10.1155/2013/598587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061615/
https://www.ncbi.nlm.nih.gov/pubmed/25006572
http://dx.doi.org/10.1155/2013/598587

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