Cargando…

uPAR and cathepsin B-mediated compartmentalization of JNK regulates the migration of glioma-initiating cells

In the present study, we investigated the effect of simultaneous downregulation of uPAR and cathepsin B (pUC), alone or in combination with radiation, on JNK–MAPK signaling pathway in regulating the migration of non-GICs (glioma-initiating cells) and GICs. The increase in the expression of p-JNK wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alapati, Kiranmai, Kesanakurti, Divya, Rao, Jasti S., Dasari, Venkata Ramesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061617/ https://www.ncbi.nlm.nih.gov/pubmed/24699410 http://dx.doi.org/10.1016/j.scr.2014.02.008

Ejemplares similares

uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells
por: ALAPATI, KIRANMAI, et al.
Publicado: (2012)

Cathepsin B and uPAR Knockdown Inhibits Tumor-induced Angiogenesis by Modulating VEGF Expression in Glioma
por: Malla, Rama Rao, et al.
Publicado: (2011)

Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas
por: Malla, Ramarao, et al.
Publicado: (2010)

Correction: Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas
por: Malla, Ramarao, et al.
Publicado: (2014)

MMP-9 and uPAR regulated glioma cell migration
por: Veeravalli, Krishna Kumar, et al.
Publicado: (2012)

Co-Depletion of Cathepsin B and uPAR Induces G0/G1 Arrest in Glioma via FOXO3a Mediated p27(Kip1) Upregulation
por: Gopinath, Sreelatha, et al.
Publicado: (2010)

Retraction: uPAR/Cathepsin B Overexpression Reverse Angiogenesis by Rescuing FAK Phosphorylation in uPAR/Cathepsin B Down Regulated Meningioma
Publicado: (2020)

MMP-9, uPAR and Cathepsin B Silencing Downregulate Integrins in Human Glioma Xenograft Cells In Vitro and In Vivo in Nude Mice
por: Veeravalli, Krishna Kumar, et al.
Publicado: (2010)

Oncogenic role of p53 is suppressed by si-RNA bicistronic construct of uPA, uPAR and cathepsin-B in meningiomas both in vitro and in vivo
por: Gupta, Reshu, et al.
Publicado: (2021)

Localization of uPAR and MMP-9 in lipid rafts is critical for migration, invasion and angiogenesis in human breast cancer cells
por: Raghu, Hari, et al.
Publicado: (2010)

Suppression of uPAR Retards Radiation-Induced Invasion and Migration Mediated by Integrin β1/FAK Signaling in Medulloblastoma
por: Nalla, Arun Kumar, et al.
Publicado: (2010)

Suppression of uPA and uPAR Attenuates Angiogenin Mediated Angiogenesis in Endothelial and Glioblastoma Cell Lines
por: Raghu, Hari, et al.
Publicado: (2010)

Integrin is on uPAR to unleash cells
por: LeBrasseur, Nicole
Publicado: (2003)

uPAR's signaling two step
por: Leslie, Mitch
Publicado: (2007)

uPAR-induced cell adhesion and migration: vitronectin provides the key
por: Madsen, Chris D., et al.
Publicado: (2007)

New Pieces in the Puzzle of uPAR Role in Cell Migration Mechanisms
por: Gorrasi, Anna, et al.
Publicado: (2020)

Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor
por: Raghu, Hari, et al.
Publicado: (2011)

Apoptosis Induced by Knockdown of uPAR and MMP-9 is Mediated by Inactivation of EGFR/STAT3 Signaling in Medulloblastoma
por: Kotipatruni, Ramaprasada Rao, et al.
Publicado: (2012)

Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR
por: Degryse, Bernard, et al.
Publicado: (2017)

uPAR: An Essential Factor for Tumor Development
por: Lv, Tao, et al.
Publicado: (2021)

Suppression of MMP-2 Attenuates TNF-α Induced NF-κB Activation and Leads to JNK Mediated Cell Death in Glioma
por: Kesanakurti, Divya, et al.
Publicado: (2011)

Secreted uPAR isoform 2 (uPAR7b) is a novel direct target of miR-221
por: Falkenberg, Natalie, et al.
Publicado: (2015)

The uPA/uPAR system in astrocytic wound healing
por: Yepes, Manuel
Publicado: (2022)

uPAR directed-imaging of head-and-neck cancer
por: Baart,, Victor M., et al.
Publicado: (2017)

Crystal structure and cellular functions of uPAR dimer
por: Yu, Shujuan, et al.
Publicado: (2022)

Retraction: Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas
Publicado: (2020)

A doxycycline-inducible urokinase receptor (uPAR) upregulates uPAR activities including resistance to anoikis in human prostate cancer cell lines
por: Hasanuzzaman, Mohammad, et al.
Publicado: (2007)

uPAR and cathepsin B shRNA impedes TGF-β1-driven proliferation and invasion of meningioma cells in a XIAP-dependent pathway
por: Gogineni, V R, et al.
Publicado: (2012)

The Urokinase Receptor (uPAR) Facilitates Clearance of Borrelia burgdorferi
por: Hovius, Joppe W. R., et al.
Publicado: (2009)

Characterization and function of human Ly-6/uPAR molecules
por: Kong, Hyun Kyung, et al.
Publicado: (2012)

First-in-human uPAR PET: Imaging of Cancer Aggressiveness
por: Persson, Morten, et al.
Publicado: (2015)

Expression of uPAR in Urinary Podocytes of Patients with Fabry Disease
por: Trimarchi, Hernán, et al.
Publicado: (2017)

uPAR-expressing melanoma exosomes promote angiogenesis by VE-Cadherin, EGFR and uPAR overexpression and rise of ERK1,2 signaling in endothelial cells
por: Biagioni, Alessio, et al.
Publicado: (2020)

COVID-19 and pneumonia: a role for the uPA/uPAR system
por: D’Alonzo, Daniele, et al.
Publicado: (2020)

Tumor-associated soluble uPAR-directed endothelial cell motility and tumor angiogenesis
por: Rao, J S, et al.
Publicado: (2013)

Clathrin and LRP-1-Independent Constitutive Endocytosis and Recycling of uPAR
por: Cortese, Katia, et al.
Publicado: (2008)

Prognostic value of uPAR expression and angiogenesis in primary and metastatic melanoma
por: Hugdahl, Emilia, et al.
Publicado: (2019)

The uPAR System as a Potential Therapeutic Target in the Diseased Eye
por: Cammalleri, Maurizio, et al.
Publicado: (2019)

Identification of uPAR Variants Acting as ceRNAs in Leukaemia Cells
por: Alfieri, Mariaevelina, et al.
Publicado: (2022)

Orientational Preferences of GPI-Anchored Ly6/uPAR Proteins
por: Zaigraev, Maxim M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_v6l5tvs78tea3l3a8mm98c7sl8