Predicting targeted drug combinations based on Pareto optimal patterns of coexpression network connectivity

BACKGROUND: Molecularly targeted drugs promise a safer and more effective treatment modality than conventional chemotherapy for cancer patients. However, tumors are dynamic systems that readily adapt to these agents activating alternative survival pathways as they evolve resistant phenotypes. Combin...

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Detalles Bibliográficos
Autores principales: Penrod, Nadia M, Greene, Casey S, Moore, Jason H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062052/
https://www.ncbi.nlm.nih.gov/pubmed/24944582
http://dx.doi.org/10.1186/gm550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062052/
https://www.ncbi.nlm.nih.gov/pubmed/24944582
http://dx.doi.org/10.1186/gm550

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