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Predicting targeted drug combinations based on Pareto optimal patterns of coexpression network connectivity
BACKGROUND: Molecularly targeted drugs promise a safer and more effective treatment modality than conventional chemotherapy for cancer patients. However, tumors are dynamic systems that readily adapt to these agents activating alternative survival pathways as they evolve resistant phenotypes. Combin...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062052/ https://www.ncbi.nlm.nih.gov/pubmed/24944582 http://dx.doi.org/10.1186/gm550 |