A genome scale overexpression screen to reveal drug activity in human cells

Target identification is a critical step in the lengthy and expensive process of drug development. Here, we describe a genome-wide screening platform that uses systematic overexpression of pooled human ORFs to understand drug mode-of-action and resistance mechanisms. We first calibrated our screen w...

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Detalles Bibliográficos
Autores principales: Arnoldo, Anthony, Kittanakom, Saranya, Heisler, Lawrence E, Mak, Anthony B, Shukalyuk, Andrey I, Torti, Dax, Moffat, Jason, Giaever, Guri, Nislow, Corey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062067/
https://www.ncbi.nlm.nih.gov/pubmed/24944581
http://dx.doi.org/10.1186/gm549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062067/
https://www.ncbi.nlm.nih.gov/pubmed/24944581
http://dx.doi.org/10.1186/gm549

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