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Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles
Human carbonic anhydrases (CAs) are zinc metalloenzymes that catalyze the hydration and dehydration of CO(2) and HCO(3) (−), respectively. The reaction follows a ping-pong mechanism, in which the rate-limiting step is the transfer of a proton from the zinc-bound solvent (OH(−)/H(2)O) in/out of the a...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062085/ https://www.ncbi.nlm.nih.gov/pubmed/25075329 http://dx.doi.org/10.1107/S2052252514004096 |