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Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles

Human carbonic anhydrases (CAs) are zinc metalloenzymes that catalyze the hydration and dehydration of CO(2) and HCO(3) (−), respectively. The reaction follows a ping-pong mechanism, in which the rate-limiting step is the transfer of a proton from the zinc-bound solvent (OH(−)/H(2)O) in/out of the a...

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Detalles Bibliográficos
Autores principales:	Aggarwal, Mayank, Kondeti, Bhargav, Tu, Chingkuang, Maupin, C. Mark, Silverman, David N., McKenna, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2014
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062085/ https://www.ncbi.nlm.nih.gov/pubmed/25075329 http://dx.doi.org/10.1107/S2052252514004096

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